Information regarding the metabolism and disposition of agrochemicals
is needed in order to assess their persistence and transport, and to establish
the identity and possible toxicological significance of the
products formed.
 Experimental Study Descriptions
PTRL West has conducted more than 200 field and greenhouse studies involving
more than forty agricultural commodities with radiolabeled agrochemicals.
Field-phase collaborators in California include Excel, Hulst,
Pacific Agriculture and Research for Hire.
The in-life phase of these studies is subcontracted to collaborators in the
US and Europe. We have considerable experience with the analytical procedures
required in the metabolism of agrochemicals and veterinary drugs in rat, goat
and hen, as well as tissue distribution, biliary excretion and blood kinetic
studies.
The analytical phase of these studies, performed in our laboratories,
involves determination of total radioactive residues (TRR), extraction of
radiolabeled species and mass balance of the incurred radiocarbon. Exhaustive
extractions and hydrolysis of conjugates as well as separation of matrix
components are profiled by chromatographic techniques and identified by comparison
to authentic standards or by GC-MS and LC-MS (MS) and NMR.
| ![[Company Logo Image]](_borders/ptrlogo.gif)
PTRL West 
